What causes pigmentary mosaicism?

Does pigmentary mosaicism go away?

Pigmentary mosaicism is a permanent color change in the skin. We are not able to change the genetic material to make the skin color the same.

How common is pigmentary mosaicism?

Most frequently, pigmentary mosaicism appears sporadically, but a family history of the condition was described in 4% of the reported cases. A rare case of two paternal half-brothers with pigmentary mosaicism of the hyperpigmented type was reported [26].

What is the most common extracutaneous involvement associated with pigmentary mosaicism?

The most frequently reported extracutaneous anomalies were skeletal deformities, seizures, mental retardation, dysmorphic facial features, and developmental delay.

Is Vitiligo a mosaic?

Clinical findings in vitiligo challenge the widely accepted organ specific autoimmune pathomechanisms. We draw the attention to the fact that the distribution of segmental vitiligo (SV) fits in at least a subset of patients a pattern usually associated with cutaneous mosaicism.

What is genetic mosaicism and how does it arise?

Mosaicism occurs when a person has two or more genetically different sets of cells in his or her body. If those abnormal cells begin to outnumber the normal cells, it can lead to disease that can be traced from the cellular level to affected tissue, like skin, the brain, or other organs.

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What is Blaschkoid Dyspigmentation?

It is also referred to as hypomelanosis of ito, Blaschkoid dyspigmentation, linear and whorled nevoid hypermelanosis and segmental pigmentation disorder. It is caused from a post-zygotic mutation of skin cells effecting melanin production and is most often sporadic.

What is Achromic nevus?

Nevus achromicus (also called nevus depigmentosus or achromic nevus) is a benign birthmark appearing as a localized area of hypopigmentation. This light colored spot is often solitary but may be present as multiple whorls or streaks.

What is segmental pigmentation disorder?

Segmental pigmentation disorder (SegPD) is a rare type of cutaneous dyspigmentation. This hereditary disorder, first described some 20 years ago, is characterized by hypo and hyperpigmented patches on the trunk, extremities and less likely on the face and neck.

What is Incontinentia?

Summary. Incontinentia pigmenti (IP) is a genetic ectodermal dysplasia affecting the skin, hair, teeth, microvasculature, and central nervous system. Progressive skin changes occur in four stages, the first of which appear in early infancy or can be present at birth.

How long does it take for Pityriasis Alba to go away?

The duration of pityriasis alba varies from 1 month to 10 years, with most cases resolving over a period of several months to a year. Diagnosis is made clinically, and treatment consists of skin care and education of a young patient’s parents about the benign nature of the disorder.

What is segmental vitiligo?

Segmental vitiligo is an uncommon form of localized vitiligo, characterized by dermatomal distribution. It is often unilateral and asymmetrical that never crosses the midline of body (1,4,5). In this form of the disease, depigmentation spots spread quickly in the affected dermatomes and then stop growing.

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